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Quantitative Image Analysis & Artificial Intelligence

An important scientific emphasis of the Department of Radiology is the development, validation and clinical application of quantitative imaging measurements. In vivo imaging measurements can be used to interrogate tissue status at different levels of analysis. These measurements have broad utility for investigating pathological processes, for diagnostics, for clinical monitoring and for evaluating interventions. Our work in AI extends from advances in automated image analysis and accelerated processing pipelines to refinements in clinical classification algorithms and risk prediction.

 Sameer Ansari

My research projects include industry-sponsored clinical studies as well as PI and Co-Investigator roles on NIH R01 and R21 projects. My goal is to study MR imaging-based risk stratification of neurovascular diseases – particularly in ischemic stroke and intracranial atherosclerotic disease. This research is put into clinical practice by increasing effectiveness of interventional treatment planning.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Daniel Kim

I am the Director of CV Imaging at the Center for Translational Imaging. My research focuses on development of rapid MRI acquisition and reconstruction methods to address unmet needs in cardiovascular medicine. Our lab focuses on breaking new grounds in cardiovascular MRI by developing innovative pulse sequences and reconstruction methods to address unmet clinical needs in cardiovascular medicine. Building upon active collaboration with radiology and cardiology colleagues, our research activities span from imaging technology development to clinical translation in cardiovascular medicine.

Currently, ongoing projects include:

  1. Role of diffuse LV fibrosis in patients with atrial fibrillation
  2. Real-time CMR for diagnosing CAD
  3. Rapid pediatric CMR without requiring contrast agent or anesthesia
  4. Advanced CMR assessment of left atrial hemodynamic disorders in atrial fibrillation
  5. Wideband CMR for predicting pre-implant right heart failure in LVAD candidates
  6. Wideband CMR for imaging patients with ICDs

For details and images, visit the Northwestern CVMRI Group page.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Virginia Hill

I have multiple projects, including texture analysis of glioblastomas treated with immunotherapy to determine radiogenomics and to differentiate between true progression and pseudoprogression, radiogenomics of gliomas in general, automatic detection of head CT emergencies, automatic detection and measurement of brain metastases on MRI.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Michael Markl

I am currently the Vice Chair of Research for the Department of Radiology. I have established a strong interdisciplinary research consortium. My research has had a major impact on the diagnosis and management of heart disease and stroke including 1) development of novel imaging techniques for the assessment of cardiac structure, function and hemodynamics, and 2) discovery of mechanisms underlying cardiovascular diseases development and cryptogenic stroke (aortic hemodynamics as a mechanism in the development of BAV aortopathy; retrograde embolization from aortic plaques and left atrial flow dynamics in atrial fibrillation as risk factors for stroke). I am internationally recognized as the pioneer of 4D flow MRI and work in this area has advanced the understanding of cardiovascular disease processes as well as enhanced patient care. I have created a highly successful and inseminating training environment in MRI technique development and translational imaging research. For details and images, visit the Northwestern CVMRI Group page.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Amber Leaver

The INMRI research group founded by Dr. Leaver at Northwestern conducts precision neuroimaging research to understand and improve electrical neuromodulation therapies. Our studies encompass several topics spanning mental health and depression, chronic idiopathic tinnitus, noninvasive electrical neuromodulation technologies, and best practices in applied connectomics. Details about my projects can be found on the Leaver Lab website.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Kai Lin

I have a broad background in quantitative cardiovascular imaging, with specific training and expertise in coronary artery MRI. My research is focusing of identify subclinical coronary artery disease (CAD) in patients suffering type 2 diabetes mellitus (T2DM). In addition, I am also interested in evaluating regional myocardial changes in patients with various clinical or subclinical cardiovascular diseases. Recently, I am developing research projects for evaluating cardiovascular responses in treating cancers, immunological and neurodegenerative disorders, such as breast cancer, systemic lupus erythematosus (SLE), Alzheimer’s disease (AD) and Parkinson’s disease (PD).​ For details and images, visit the Northwestern CVMRI Group page.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Todd Parrish

I have a strong expertise in image processing and neuroimaging with a special emphasis on MR based methods. My group and I have been successful in using advanced neuroimaging methods to demonstrate changes in BOLD, diffusion, perfusion, magnetization transfer and structural measures associated with function, memory and learning in the brain as well as movement, sensory, and pain in the spinal cord. I have a long history of methods development and application of neuroimaging methods to pathologic and clinical conditions. My current interests are developing novel methodologies to explore brain physiology to generate new imaging techniques to study the brain. These areas include neurovascular physiology, perfusion/permeability in tissue, multimodal imaging and image analysis, mechanisms of spinal cord structure and function, the use of infrared thermometry for intraoperative functional mapping in awake surgery, and application of machine learning to medical images. I have extensive experience conducting multi-center neuroimaging studies and understand the issues well.​ For details and images, visit the Parrish Neuroimaging Laboratory.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Ann Ragin

My research projects include Quantitative Magnetic Resonance Imaging strategies for in vivo measurement of the brain to investigate effects of aging and of viruses, particularly HIV infection. Brain network analysis to investigate effects of aging and for early detection of neural injury. Collaborative projects involve applications of 4D flow imaging to investigate alterations in cerebral blood flow and relation to brain status. For details and images, visit the Northwestern CVMRI Group page.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Susanne Schnell

My current work focuses on intracranial 4D Flow MRI: The brain vasculature is a complex flow network with a large range of velocities and patient anatomy, and interest in quantitative brain imaging biomarkers is growing. 4D Flow is used in a variety of neurovascular applications to quantify the impact of disease on local hemodynamics and flow distributions throughout the whole brain. Running projects concentrate on healthy cohorts as well as intracranial arteriovenous malformation (AVM) and vein of galen aneurysmal malformation, intracranial aneurysm patients as well as intracranial atherosclerosis. For details and images, visit the Intracranial 4D Flow website and the Northwestern CVMRI Group page.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Zhuoli Zhang

I am the Manager of Quality and Regulatory Affairs at the Northwestern Quantitative Imaging Core Lab in the Robert H. Lurie Comprehensive Cancer Center. For the last 15 years, I have been actively involved in magnetic resonance imaging (MRI), cancer immunology, and with 12 years devoted specifically to the development and validation of MRI techniques for assessing of cancer therapies. I expanded my research to include MRI monitoring of immune therapies and evaluating therapy responses with quantitative MRI biomarkers.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Google Scholars.

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