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Molecular, Preclinical & Nanomedicine

Our scientists work on novel treatment of various types of cancer using models to optimize and develop MRI sequences. Image-guided treatments focus on multifunctional carriers of therapeutic drugs, targeted and combination cell therapy and immunotherapy utilizing natural killer and dendritic cells. These teams of investigators collaborate with clinicians, medical scientists, biologists and imaging professionals to translate these new cancer therapy approaches into diagnostic imaging technique and treatment in the clinical setting.

 Dong-Hyun Kim

Image-guided medicine is rapidly growing to improve treatment regimens and advancing medical imaging, including magnetic resonance imaging (MRI), computed tomography (CT), radiography, ultrasound, positron emission tomography (PET), and single photon emission computed tomography (SPECT). A combination of modern nanoplatforms with high performance in imaging and therapeutics may be critical to improve medical outcomes.

One of emerging fields is image-guided therapy using various nanoparticles. Therapies include basic bench, preclinical in vitro/in vivo and clinical researches combining synthesis of multifunctional nanoparticle and tracking/navigation tools to improve accuracy and outcomes of the therapeutics. Most of the emerging interventional technique such as heat-activated targeted drug delivery, image guided ablation (microwave or HIFU), percutaneous injection gene/bacteria therapy, transcatheter treatments for tumor specific local therapy, serial biopsy, thrombolytic therapy, and so on, can be combined with nanotechnology in clinic.

My research engages in careful design/selection/synthesis of multifunctional imaging/therapeutic nanomaterials with therapeutic agents will be critical for the translational optimization these new image guided medicine techniques. The DHKIM Lab for Biomaterials​ of Image Guided NanoMedicine has focused on developing various therapeutic/imaging carriers for the treatment of various cancers. Micro/Nanoparticles and their hybrid derivatives have been exploited as vectors for drug/therapeutic delivery and molecular imaging agents of MRI, CT, ultrasound and luminescent/fluorescents. We are working closely with clinicians, medical scientists, biologist and imaging professionals to translate new therapeutic approaches using multifunctional carriers and diagnostic imaging technique to the clinical setting.

Lab Manager: Xiaoke Huang

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Daniele Procissi

My research projects focuses on preclinical Molecular Imaging using MRI, PET and CT.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Yury Velichko

My scientific interests overlap in the areas of biomaterials, anticancer drug development, quantitative imaging and therapeutic response assessment. With a background in molecular physics and informatics, I strive to apply concepts from one field to questions in another. I am also the manager of the Quantitative Imaging Core Laboratory (QICL) at Northwestern University - Feinberg School of Medicine.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Northwestern Scholars.

 Bo Yu

For further details and images, visit the Nano/Micro BIGMED Lab page.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

 Zhuoli Zhang

I am the Manager of Quality and Regulatory Affairs at the Northwestern Quantitative Imaging Core Lab in the Robert H. Lurie Comprehensive Cancer Center. For the last 15 years, I have been actively involved in magnetic resonance imaging (MRI), cancer immunology, and with 12 years devoted specifically to the development and validation of MRI techniques for assessing of cancer therapies. I expanded my research to include MRI monitoring of immune therapies and evaluating therapy responses with quantitative MRI biomarkers.

For more information on my research, please view my Feinberg School of Medicine faculty profile.

Publications

View my publications on Google Scholars.

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